

| Каталожный номер | HA508014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human RAB27A Polyclonal Antibody (HA508014) is a rabbit polyclonal antibody detecting RAB27A in ELISA, IHC, WB. Suitable for Rattus norvegicus, Mus musculus, Human, and Sus scrofa.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human RAB27A (Met1-Lys191). | ||||||||
| Цель | RAB27A | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P51159 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Альтернативные названия | Ras-related protein Rab-27A, Rab-27, 3.6.5.2, GTP-binding protein Ram, RAB27A, RAB27 | ||||||||
| Фон | Ras-related protein Rab-27A (RAB27A) is a ~24 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB27A regulates homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. 1. Zhang, J. et al. (2019) Biochimica et biophysica acta. Molecular cell research 1866, 916-929. PMID: 30771381 2. Ménasché, G. et al. (2008) Blood 112, 5052-62. PMID: 18812475 | ||||||||
| Примечание | For research use only. |
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