

| Numéro de catalogue | HT029014 | ||||||||
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| Description |
Anti-Human RAB27B Polyclonal Antibody (HT029014) is a rabbit polyclonal antibody detecting RAB27B in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.
Highlights
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| Reactivité des espèces | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human RAB27B (Met1-Asp196). | ||||||||
| Cible | RAB27B, Ras-related protein Rab-27B, C25KG | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | O00194 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Ras-related protein Rab-27B (RAB27B) is a ~24 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB27B regulates homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1. May be involved in targeting uroplakins to urothelial apical membranes. 1. Huang, SH. et al. (2011) The Journal of neuroscience : the official journal of the Society for Neuroscience 31, 10602-14. PMID: 21775604 2. Zhang, J. et al. (2019) Biochimica et biophysica acta. Molecular cell research 1866, 916-929. PMID: 30771381 | ||||||||
| Note | For research use only. |
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