Anti-Human RAB2A Polyclonal Antibody (HX083014)

Name: Anti-Human RAB2A Polyclonal Antibody
Brand: abinScience
SKU: HX083014
Price: 168 USD
Availability: InStock

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SDS

Обзор

Каталожный номер

HX083014

Описание

Anti-Human RAB2A Polyclonal Antibody (HX083014) is a rabbit polyclonal antibody detecting RAB2A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Dog, and Chicken.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human RAB2A (Met1-Gly188).

Цель

RAB2A, Ras-related protein Rab-2A, RAB2

Очистка

Purified by antigen affinity column.

Номер доступа

P61019

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Ras-related protein Rab-2A (RAB2A) is a ~23 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion. Required for protein transport from the endoplasmic reticulum to the Golgi complex.

1. Zhang, S. et al. (2023) Nature communications 14, 6360. PMID: 37821429

2. Aizawa, M. et al. (2015) The Journal of biological chemistry 290, 22250-61. PMID: 26209634

3. Lőrincz, P. et al. (2017) The Journal of cell biology 216, 1937-1947. PMID: 28483915

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human RAB2A Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

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