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| カタログ番号 | HD207014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RAB32 Polyclonal Antibody (HD207014) is a rabbit polyclonal antibody detecting RAB32. Suitable for Human.
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RAB32 (Met1-Cys225). | ||||||||
| ターゲット | EC:3.6.5.2, RAB32, Ras-related protein Rab-32 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13637 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Ras-related protein Rab-32 (RAB32) is a ~24 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Also acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. 1. Bao, X. et al. (2002) European journal of biochemistry 269, 259-71. PMID: 11784320 2. Nottingham, RM. et al. (2011) The Journal of biological chemistry 286, 33213-22. PMID: 21808068 3. Alto, NM. et al. (2002) The Journal of cell biology 158, 659-68. PMID: 12186851 4. Seto, S. et al. (2011) Traffic (Copenhagen, Denmark) 12, 407-20. PMID: 21255211 5. Gerondopoulos, A. et al. (2012) Current biology : CB 22, 2135-9. PMID: 23084991 6. Zhu, H. et al. (2023) Science (New York, N.Y.) 382, 1404-1411. PMID: 38127736 | ||||||||
| 注意事項 | For research use only |
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