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| カタログ番号 | HP954025 |
|---|---|
| 説明 |
Anti-Human RAB39B Monoclonal Antibody (1A444) [1A444] (HP954025) is a mouse monoclonal antibody detecting RAB39B in ELISA, WB. Suitable for Human.
Highlights
|
| 種反応性 | Human |
| アプリケーション | ELISA, WB |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1 |
| クローンID | 1A444 |
| 免疫原 | Recombinant Human RAB39B protein. |
| ターゲット | Ras-related protein Rab-39B, RAB39B |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q96DA2 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Ras-related protein Rab-39B (RAB39B) is a ~24 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB39B is involved in autophagy and may function in autophagosome formation. Binds downstream effector PICK1 to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR composition at the post-synapses and thus synaptic transmission. May regulate the homeostasis of SNCA/alpha-synuclein. 1. Sellier, C. et al. (2016) The EMBO journal 35, 1276-97. PMID: 27103069 2. Zhang, S. et al. (2023) Nature communications 14, 6360. PMID: 37821429 |
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human RAB39B Monoclonal Antibody (1A444)
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