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| カタログ番号 | HB975014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RAB3A Polyclonal Antibody (HB975014) is a rabbit polyclonal antibody detecting RAB3A in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RAB3A (Asp20-Thr193). | ||||||||
| ターゲット | Ras-related protein Rab-3A, RAB3A | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P20336 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ras-related protein Rab-3A (RAB3A) is a ~24 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB3A plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane. 1. Zahraoui, A. et al. (1989) The Journal of biological chemistry 264, 12394-401. PMID: 2501306 2. Encarnação, M. et al. (2016) The Journal of cell biology 213, 631-40. PMID: 27325790 3. Bello, OD. et al. (2012) Experimental cell research 318, 478-88. PMID: 22248876 4. Quevedo, MF. et al. (2019) Biochimica et biophysica acta. Molecular cell research 1866, 612-622. PMID: 30599141 | ||||||||
| 注意事項 | For research use only. |
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