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| カタログ番号 | HC686014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RAB3GAP1 Polyclonal Antibody (HC686014) is a rabbit polyclonal antibody detecting RAB3GAP1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RAB3GAP1 (Met646-Asp756). | ||||||||
| ターゲット | Rab3 GTPase-activating protein catalytic subunit, RAB3 GTPase-activating protein 130 kDa subunit, Rab3-GAP p130, Rab3-GAP, RAB3GAP1, KIAA0066, RAB3GAP | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q15042 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Rab3 GTPase-activating protein catalytic subunit (RAB3GAP1) is a ~110 kDa protein. Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which accelerates the otherwise slow GTP hydrolysis catalyzed by Rab proteins. Has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43. Additionally, it has guanine nucleotide exchange factor (GEF) activity towards RAB18, promoting GDP release from RAB18 and the conversion of inactive RAB18-GDP to the active form RAB18-GTP. Recruits and stabilizes RAB18 at the cis-Golgi membrane in fibroblasts where RAB18 is most likely activated. Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure. 1. Fukui, K. et al. (1997) The Journal of biological chemistry 272, 4655-8. PMID: 9030515 2. Clabecq, A. et al. (2000) The Journal of biological chemistry 275, 31786-91. PMID: 10859313 3. Fairlie, GMJ. et al. (2025) Nature communications 16, 479. PMID: 39779760 4. Gerondopoulos, A. et al. (2014) The Journal of cell biology 205, 707-20. PMID: 24891604 5. Handley, MT. et al. (2015) Open biology 5, 150047. PMID: 26063829 | ||||||||
| 注意事項 | For research use only. |
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