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| カタログ番号 | HP867014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RAB3IP Polyclonal Antibody (HP867014) is a rabbit polyclonal antibody detecting RAB3IP in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RAB3IP (Asp314-Leu476). | ||||||||
| ターゲット | Rabin-3, Rab3A-interacting protein, Rab-3A-interacting protein, SSX2-interacting protein, RAB3IP, RABIN8 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96QF0 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Rab-3A-interacting protein (RAB3IP) is a ~53 kDa protein. Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. 1. Hattula, K. et al. (2002) Molecular biology of the cell 13, 3268-80. PMID: 12221131 2. Steger, M. et al. (2016) eLife 5. PMID: 26824392 3. Yoshimura, S. et al. (2010) The Journal of cell biology 191, 367-81. PMID: 20937701 4. Bryant, DM. et al. (2010) Nature cell biology 12, 1035-45. PMID: 20890297 5. Wang, J. et al. (2015) Journal of cell science 128, 1375-85. PMID: 25673879 6. Walia, V. et al. (2019) Developmental cell 50, 229-246.e7. PMID: 31204173 | ||||||||
| 注意事項 | For research use only. |
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