

| Каталожный номер | HP867014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human RAB3IP Polyclonal Antibody (HP867014) is a rabbit polyclonal antibody detecting RAB3IP in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human RAB3IP (Asp314-Leu476). | ||||||||
| Цель | Rabin-3, Rab3A-interacting protein, Rab-3A-interacting protein, SSX2-interacting protein, RAB3IP, RABIN8 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q96QF0 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Rab-3A-interacting protein (RAB3IP) is a ~53 kDa protein. Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. 1. Hattula, K. et al. (2002) Molecular biology of the cell 13, 3268-80. PMID: 12221131 2. Steger, M. et al. (2016) eLife 5. PMID: 26824392 3. Yoshimura, S. et al. (2010) The Journal of cell biology 191, 367-81. PMID: 20937701 4. Bryant, DM. et al. (2010) Nature cell biology 12, 1035-45. PMID: 20890297 5. Wang, J. et al. (2015) Journal of cell science 128, 1375-85. PMID: 25673879 6. Walia, V. et al. (2019) Developmental cell 50, 229-246.e7. PMID: 31204173 | ||||||||
| Примечание | For research use only. |
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