Anti-Human RAB8A Polyclonal Antibody (HX163014)

Name: Anti-Human RAB8A Polyclonal Antibody
Brand: abinScience
SKU: HX163014
Price: 168 USD
Availability: InStock

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50ug
100ug

Número:

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Número de catálogo

HX163014

Descripción

Anti-Human RAB8A Polyclonal Antibody (HX163014) is a rabbit polyclonal antibody detecting RAB8A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Dog.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human RAB8A (Lys21-Ser181).

Objetivo

RAB8, MEL, Ras-related protein Rab-8A, Oncogene c-mel, RAB8A

Purificación

Purified by antigen affinity column.

Número de acceso

P61006

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Ras-related protein Rab-8A (RAB8A) is a ~23 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB8A is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Regulates the compacted morphology of the Golgi.

1. Bryant, DM. et al. (2010) Nature cell biology 12, 1035-45. PMID: 20890297

2. Aizawa, M. et al. (2015) The Journal of biological chemistry 290, 22250-61. PMID: 26209634

3. Roland, JT. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2789-94. PMID: 21282656

4. Chen, Y. et al. (2012) Cell research 22, 333-45. PMID: 21844891

5. Dhekne, HS. et al. (2018) eLife 7. PMID: 30398148

6. Murga-Zamalloa, CA. et al. (2010) Human molecular genetics 19, 3591-8. PMID: 20631154

7. Sellier, C. et al. (2016) The EMBO journal 35, 1276-97. PMID: 27103069

8. Lucken-Ardjomande Häsler, S. et al. (2020) The Journal of cell biology 219. PMID: 32344433

9. Eguchi, T. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E9115-E9124. PMID: 30209220

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human RAB8A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human RAB8A Polyclonal Antibody (HX163014)

Vista general

Imágenes

Referencias

Datasheet

SDS