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| カタログ番号 | HX163014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RAB8A Polyclonal Antibody (HX163014) is a rabbit polyclonal antibody detecting RAB8A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Dog.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RAB8A (Lys21-Ser181). | ||||||||
| ターゲット | RAB8, MEL, Ras-related protein Rab-8A, Oncogene c-mel, RAB8A | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P61006 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ras-related protein Rab-8A (RAB8A) is a ~23 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB8A is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Regulates the compacted morphology of the Golgi. 1. Bryant, DM. et al. (2010) Nature cell biology 12, 1035-45. PMID: 20890297 2. Aizawa, M. et al. (2015) The Journal of biological chemistry 290, 22250-61. PMID: 26209634 3. Roland, JT. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2789-94. PMID: 21282656 4. Chen, Y. et al. (2012) Cell research 22, 333-45. PMID: 21844891 5. Dhekne, HS. et al. (2018) eLife 7. PMID: 30398148 6. Murga-Zamalloa, CA. et al. (2010) Human molecular genetics 19, 3591-8. PMID: 20631154 7. Sellier, C. et al. (2016) The EMBO journal 35, 1276-97. PMID: 27103069 8. Lucken-Ardjomande Häsler, S. et al. (2020) The Journal of cell biology 219. PMID: 32344433 9. Eguchi, T. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E9115-E9124. PMID: 30209220 | ||||||||
| 注意事項 | For research use only. |
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