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| カタログ番号 | HX977014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RACK1 Polyclonal Antibody (HX977014) is a rabbit polyclonal antibody detecting RACK1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RACK1 (Met1-Arg317). | ||||||||
| ターゲット | RACK1, Human lung cancer oncogene 7 protein, Guanine nucleotide-binding protein subunit beta-like protein 12.3, GNB2L1, Cell proliferation-inducing gene 21 protein, Guanine nucleotide-binding protein subunit beta-2-like 1, Receptor of activated protein C kinase 1, Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed, Receptor for activated C kinase, Small ribosomal subunit protein RACK1, HLC-7 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P63244 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Small ribosomal subunit protein RACK1 is a ~35 kDa protein. Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. 1. Anger, AM. et al. (2013) Nature 497, 80-5. PMID: 23636399 2. Sundaramoorthy, E. et al. (2017) Molecular cell 65, 751-760.e4. PMID: 28132843 3. Ikebuchi, Y. et al. (2009) Hepatology research : the official journal of the Japan Society of Hepatology 39, 1091-107. PMID: 19674157 4. Cao, XX. et al. (2011) Breast cancer research and treatment 126, 555-63. PMID: 20499158 | ||||||||
| 注意事項 | For research use only. |
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