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Anti-Human RAD17 Polyclonal Antibody (HF857014)

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Vista general
Número de catálogoHF857014
Descripción
Anti-Human RAD17 Polyclonal Antibody (HF857014) is a rabbit polyclonal antibody detecting RAD17 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human RAD17 (Lys96-Pro353).
Objetivo Cell cycle checkpoint protein RAD17, hRad17, RF-C/activator 1 homolog, RAD17, R24L
Purificación Purified by antigen affinity column.
Número de acceso O75943
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Cell cycle checkpoint protein RAD17 is a ~77 kDa protein. Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation. Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites. May also serve as a sensor of DNA replication progression.

1. Li, L. et al. (1999) Oncogene 18, 1689-99. PMID: 10208430
2. Bao, S. et al. (2001) Nature 411, 969-74. PMID: 11418864
3. Post, S. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 13102-7. PMID: 11687627
4. Zou, L. et al. (2002) Genes & development 16, 198-208. PMID: 11799063
5. Wang, X. et al. (2003) Genes & development 17, 965-70. PMID: 12672690
6. Ellison, V. et al. (2003) PLoS biology 1, E33. PMID: 14624239
7. Garg, R. et al. (2004) Molecular cancer research : MCR 2, 362-9. PMID: 15235112
8. Cotta-Ramusino, C. et al. (2011) Science (New York, N.Y.) 332, 1313-7. PMID: 21659603
10. Bermudez, VP. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 1633-8. PMID: 12578958
Nota For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human RAD17 Polyclonal Antibody

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