Anti-Human RAN Polyclonal Antibody (HX918014)

Name: Anti-Human RAN Polyclonal Antibody
Brand: abinScience
SKU: HX918014
Price: 168 USD
Availability: InStock

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Каталожный номер

HX918014

Описание

Anti-Human RAN Polyclonal Antibody (HX918014) is a rabbit polyclonal antibody detecting RAN in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human RAN (Met1-Asp171).

Цель

GTP-binding nuclear protein Ran, 3.6.5.-, Androgen receptor-associated protein 24, GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein, RAN, ARA24, OK/SW-cl.81

Очистка

Purified by antigen affinity column.

Номер доступа

P62826

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

GTP-binding nuclear protein Ran is a ~24 kDa protein. GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins.

1. Hsiao, PW. et al. (1999) The Journal of biological chemistry 274, 20229-34. PMID: 10400640

2. Yamashita, D. et al. (2007) The Journal of biological chemistry 282, 7563-75. PMID: 17209048

3. Rudack, T. et al. (2015) The Journal of biological chemistry 290, 24079-90. PMID: 26272610

4. Aksu, M. et al. (2016) Nature communications 7, 11952. PMID: 27306458

5. Melchior, F. et al. (1993) The Journal of cell biology 123, 1649-59. PMID: 8276887

6. Palacios, I. et al. (1996) The Journal of cell biology 133, 485-94. PMID: 8636225

7. Moroianu, J. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 7059-62. PMID: 8692944

8. Görlich, D. et al. (1996) The EMBO journal 15, 5584-94. PMID: 8896452

9. Izaurralde, E. et al. (1997) The EMBO journal 16, 6535-47. PMID: 9351834

10. Bischoff, FR. et al. (1997) FEBS letters 419, 249-54. PMID: 9428644

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human RAN Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

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Anti-Human RAN Polyclonal Antibody (HX918014)

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