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| カタログ番号 | HY385014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RARB Polyclonal Antibody (HY385014) is a rabbit polyclonal antibody detecting RARB in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RARB (Leu205-Ser451). | ||||||||
| ターゲット | Retinoic acid receptor beta, Nuclear receptor subfamily 1 group B member 2, RARB, HBV-activated protein, RAR-beta, RAR-epsilon, NR1B2, HAP | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P10826 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Retinoic acid receptor beta (RARB) is a ~50 kDa protein. Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element. 1. Hauksdottir, H. et al. (2003) Molecular endocrinology (Baltimore, Md.) 17, 373-85. PMID: 12554770 2. Chandra, V. et al. (2017) Nature communications 8, 868. PMID: 29021580 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-RARB polyclonal antibody at 1ug/mL on various samples.
Lane 1: HUVEC cell lysate
Lane 2: A431 cell lysate
Lane 3: A549 cell lysate
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