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Anti-Human RBM8A Polyclonal Antibody (HP600014)

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Aperçu
Numéro de catalogueHP600014
Description
Anti-Human RBM8A Polyclonal Antibody (HP600014) is a rabbit polyclonal antibody detecting RBM8A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human RBM8A (Gly72-Arg152).
Cible Ribonucleoprotein RBM8A, RNA-binding protein Y14, RNA-binding motif protein 8A, BOV-1, RBM8A, Binder of OVCA1-1, RBM8, RNA-binding protein 8A
Purification Purified by antigen affinity column.
Numéro d'accès Q9Y5S9
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

RNA-binding protein 8A (RBM8A) is a ~19 kDa protein. Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation.

1. Zhang, X. et al. (2017) Cell 169, 918-929.e14. PMID: 28502770
2. Zhan, X. et al. (2018) Science (New York, N.Y.) 359, 537-545. PMID: 29301961
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Working Solution
C₂ (Working Conc.)
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