Anti-Human RBPJ Polyclonal Antibody (HC340014)

Name: Anti-Human RBPJ Polyclonal Antibody
Brand: abinScience
SKU: HC340014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HC340014

Description

Anti-Human RBPJ Polyclonal Antibody (HC340014) is a rabbit polyclonal antibody detecting RBPJ in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human RBPJ (Arg30-Gly345).

Cible

Recombining binding protein suppressor of hairless, RBP-J, IGKJRB, CBF-1, J kappa-recombination signal-binding protein, RBP-J kappa, RBP-JK, IGKJRB1, RBPJ, Renal carcinoma antigen NY-REN-30, RBPSUH, RBPJK

Purification

Purified by antigen affinity column.

Numéro d'accès

Q06330

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Recombining binding protein suppressor of hairless (RBPJ) is a ~55 kDa protein. Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence.

1. Bartels, SJ. et al. (2011) PloS one 6, e25884. PMID: 21991380

2. Aras, S. et al. (2013) Nucleic acids research 41, 2255-66. PMID: 23303788

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human RBPJ Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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