Anti-Human RECQL5 Polyclonal Antibody (HF650014)

Name: Anti-Human RECQL5 Polyclonal Antibody
Brand: abinScience
SKU: HF650014
Price: 168 USD
Availability: InStock

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Especificación:

50ug
100ug

Número:

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Vista general

Número de catálogo

HF650014

Descripción

Anti-Human RECQL5 Polyclonal Antibody (HF650014) is a rabbit polyclonal antibody detecting RECQL5 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human RECQL5 (Asp11-Thr218).

Objetivo

ATP-dependent DNA helicase Q5, 5.6.2.4, DNA 3'-5' helicase RecQ5, DNA helicase, RecQ-like type 5, RecQ5, RecQ protein-like 5, RECQL5, RECQ5

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Purified by antigen affinity column.

Número de acceso

O94762

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

ATP-dependent DNA helicase Q5 (RECQL5) is a ~108 kDa protein. DNA helicase that plays an important role in DNA replication, transcription and repair. Probably unwinds DNA in a 3'-5' direction (Probable). Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability. Also associates with POLR1A and enforces the stability of ribosomal DNA arrays. Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress.

1. Blundred, R. et al. (2010) DNA repair 9, 964-75. PMID: 20643585

2. Tadokoro, T. et al. (2012) Molecular biology of the cell 23, 4273-85. PMID: 22973052

3. Newman, JA. et al. (2017) Nucleic acids research 45, 4231-4243. PMID: 28100692

4. Islam, MN. et al. (2010) Molecular and cellular biology 30, 2460-72. PMID: 20231364

5. Urban, V. et al. (2016) The Journal of cell biology 214, 401-15. PMID: 27502483

6. Ramamoorthy, M. et al. (2012) Nucleic acids research 40, 1621-35. PMID: 22013166

7. Di Marco, S. et al. (2017) Molecular cell 66, 658-671.e8. PMID: 28575661

8. Ramamoorthy, M. et al. (2013) Carcinogenesis 34, 2218-30. PMID: 23715498

Nota

For research use only.

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