Anti-Human RICTOR Polyclonal Antibody (HP601014)

Name: Anti-Human RICTOR Polyclonal Antibody
Brand: abinScience
SKU: HP601014
Price: 168 USD
Availability: InStock

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Prix(USD) :

Spécification :

50ug
100ug

Nombre :

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Aperçu
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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HP601014

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human RICTOR (Arg32-Glu140).

Cible

KIAA1999, Rapamycin-insensitive companion of mTOR, hAVO3, RICTOR, AVO3 homolog

Purification

Purified by antigen affinity column.

Numéro d'accès

Q6R327

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Rapamycin-insensitive companion of mTOR (RICTOR) is a ~192 kDa protein. Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output. In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1. In contrast to mTORC1, mTORC2 is nutrient-insensitive. Within the mTORC2 complex, RICTOR probably acts as a molecular adapter. RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2.

1. Sarbassov, DD. et al. (2004) Current biology : CB 14, 1296-302. PMID: 15268862

2. Sarbassov, DD. et al. (2005) Science (New York, N.Y.) 307, 1098-101. PMID: 15718470

3. Dibble, CC. et al. (2009) Molecular and cellular biology 29, 5657-70. PMID: 19720745

4. Julien, LA. et al. (2010) Molecular and cellular biology 30, 908-21. PMID: 19995915

5. Chen, CH. et al. (2011) Science signaling 4, ra10. PMID: 21343617

6. Scaiola, A. et al. (2020) Science advances 6. PMID: 33158864

7. Zhuang, L. et al. (2022) Cell biology international 46, 1693-1703. PMID: 35904232

8. Yu, Z. et al. (2022) The Journal of biological chemistry 298, 102288. PMID: 35926713

9. Treins, C. et al. (2010) Oncogene 29, 1003-16. PMID: 19935711

10. Jacinto, E. et al. (2004) Nature cell biology 6, 1122-8. PMID: 15467718

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human RICTOR Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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