Anti-Human RICTOR Polyclonal Antibody (HP601014)

Name: Anti-Human RICTOR Polyclonal Antibody
Brand: abinScience
SKU: HP601014
Price: 168 USD
Availability: InStock

データシート製品共有情報コピー

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100ug

数量:

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HP601014

種反応性

Human, Mouse

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human RICTOR (Arg32-Glu140).

ターゲット

KIAA1999, Rapamycin-insensitive companion of mTOR, hAVO3, RICTOR, AVO3 homolog

精製

Purified by antigen affinity column.

アクセッション番号

Q6R327

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Rapamycin-insensitive companion of mTOR (RICTOR) is a ~192 kDa protein. Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output. In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1. In contrast to mTORC1, mTORC2 is nutrient-insensitive. Within the mTORC2 complex, RICTOR probably acts as a molecular adapter. RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2.

1. Sarbassov, DD. et al. (2004) Current biology : CB 14, 1296-302. PMID: 15268862

2. Sarbassov, DD. et al. (2005) Science (New York, N.Y.) 307, 1098-101. PMID: 15718470

3. Dibble, CC. et al. (2009) Molecular and cellular biology 29, 5657-70. PMID: 19720745

4. Julien, LA. et al. (2010) Molecular and cellular biology 30, 908-21. PMID: 19995915

5. Chen, CH. et al. (2011) Science signaling 4, ra10. PMID: 21343617

6. Scaiola, A. et al. (2020) Science advances 6. PMID: 33158864

7. Zhuang, L. et al. (2022) Cell biology international 46, 1693-1703. PMID: 35904232

8. Yu, Z. et al. (2022) The Journal of biological chemistry 298, 102288. PMID: 35926713

9. Treins, C. et al. (2010) Oncogene 29, 1003-16. PMID: 19935711

10. Jacinto, E. et al. (2004) Nature cell biology 6, 1122-8. PMID: 15467718

注意事項

For research use only.

イメージ

参考文献

データシート

Anti-Human RICTOR Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-Human RICTOR Polyclonal Antibody (HP601014)

概要

イメージ

参考文献

データシート

SDS

クイックアクセス

お問い合わせ