Anti-Human RIOX1/C14ORF169 IP Recombinant Antibody (SAA0194) (HP392013)

Name: Anti-Human RIOX1/C14ORF169 IP Recombinant Antibody (SAA0194)
Brand: abinScience
SKU: HP392013
Price: 191 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HP392013

Reactividad de especies

Human

Aplicaciones

ELISA, IF, IP

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a

ID de clon

SAA0194

Objetivo

ROX, MAPJD, C14orf169, hsNO66, Myc-associated protein with JmjC domain, Ribosomal oxygenase 1, Nucleolar protein 66, Ribosomal oxygenase NO66, Histone lysine demethylase NO66, 60S ribosomal protein L8 histidine hydroxylase, NO66, Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, RIOX1

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

Q9H6W3

RRID

Anti-Human RIOX1/C14ORF169 IP Antibody (SAA0194) (abinScience Cat# HP392013, RRID:AB_3729728)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

Ribosomal oxygenase 1 (RIOX1/C14ORF169) is a ~71 kDa protein. Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation.

1. Ge, W. et al. (2012) Nature chemical biology 8, 960-962. PMID: 23103944

2. Suzuki, C. et al. (2007) Molecular cancer therapeutics 6, 542-51. PMID: 17308053

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human RIOX1/C14ORF169 IP Antibody (SAA0194)

Referencias

Datasheet

Anti-Human RIOX1/C14ORF169 IP Recombinant Antibody (SAA0194).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo