Anti-Human RIOX1/C14ORF169 IP Recombinant Antibody (SAA0194) (HP392013)

Name: Anti-Human RIOX1/C14ORF169 IP Recombinant Antibody (SAA0194)
Brand: abinScience
SKU: HP392013
Price: 191 USD
Availability: InStock

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Prix(USD) :

Spécification :

50ug
100ug
1mg

Nombre :

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HP392013

Reactivité des espèces

Human

Applications

ELISA, IF, IP

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a

ID de clone

SAA0194

Cible

ROX, MAPJD, C14orf169, hsNO66, Myc-associated protein with JmjC domain, Ribosomal oxygenase 1, Nucleolar protein 66, Ribosomal oxygenase NO66, Histone lysine demethylase NO66, 60S ribosomal protein L8 histidine hydroxylase, NO66, Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, RIOX1

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

Q9H6W3

RRID

Anti-Human RIOX1/C14ORF169 IP Antibody (SAA0194) (abinScience Cat# HP392013, RRID:AB_3729728)

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

Ribosomal oxygenase 1 (RIOX1/C14ORF169) is a ~71 kDa protein. Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation.

1. Ge, W. et al. (2012) Nature chemical biology 8, 960-962. PMID: 23103944

2. Suzuki, C. et al. (2007) Molecular cancer therapeutics 6, 542-51. PMID: 17308053

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human RIOX1/C14ORF169 IP Antibody (SAA0194)

Reférences

Fiche technique

Anti-Human RIOX1/C14ORF169 IP Recombinant Antibody (SAA0194).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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