中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HC625014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RNASEL Polyclonal Antibody (HC625014) is a rabbit polyclonal antibody detecting RNASEL in ELISA, IHC, WB. Suitable for Human.
Highlights
|
||||||||
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RNASEL (Ile358-His583). | ||||||||
| ターゲット | Ribonuclease L, Ribonuclease 4, 2-5A-dependent RNase, 2-5A-dependent ribonuclease, RNS4, RNASEL, RNase L | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q05823 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | 2-5A-dependent ribonuclease (RNASEL) is a ~83 kDa protein. Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis. 1. Le Roy, F. et al. (2001) The Journal of biological chemistry 276, 48473-82. PMID: 11585831 2. Siddiqui, MA. et al. (2015) International journal of molecular sciences 16, 17611-36. PMID: 26263979 3. Huai, W. et al. (2025) Immunity 58, 797-810.e6. PMID: 40010341 | ||||||||
| 注意事項 | For research use only. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
