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| カタログ番号 | HA313014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RNF186 Polyclonal Antibody (HA313014) is a rabbit polyclonal antibody detecting RNF186 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RNF186 (Gly32-Val150). | ||||||||
| ターゲット | RNF186, RING finger protein 186, E3 ubiquitin-protein ligase RNF186 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9NXI6 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | E3 ubiquitin-protein ligase RNF186 is a ~24 kDa protein. E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress. Stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis. Plays a role in the maintenance of intestinal homeostasis and clearance of enteric pathogens. Upon NOD2 stimulation, ubiquitinates the ER stress sensor activating transcription factor 6/ATF6 and promotes the unfolded protein response UPR. Participates in basal level of autophagy maintenance by regulating the ubiquitination of EPHB2 and EPHB3. 1. Wang, P. et al. (2013) Cellular signalling 25, 2320-33. PMID: 23896122 2. Ranjan, K. et al. (2021) The Journal of clinical investigation 131. PMID: 34623328 3. Zhang, H. et al. (2021) Autophagy 17, 3030-3047. PMID: 33280498 4. Lear, TB. et al. (2019) The Journal of biological chemistry 294, 16527-16534. PMID: 31586034 | ||||||||
| 注意事項 | For research use only. |
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