Anti-Human RNF186 Polyclonal Antibody (HA313014)

Name: Anti-Human RNF186 Polyclonal Antibody
Brand: abinScience
SKU: HA313014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HA313014

Описание

Anti-Human RNF186 Polyclonal Antibody (HA313014) is a rabbit polyclonal antibody detecting RNF186 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human RNF186 (Gly32-Val150).

Цель

RNF186, RING finger protein 186, E3 ubiquitin-protein ligase RNF186

Очистка

Purified by antigen affinity column.

Номер доступа

Q9NXI6

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

E3 ubiquitin-protein ligase RNF186 is a ~24 kDa protein. E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress. Stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis. Plays a role in the maintenance of intestinal homeostasis and clearance of enteric pathogens. Upon NOD2 stimulation, ubiquitinates the ER stress sensor activating transcription factor 6/ATF6 and promotes the unfolded protein response UPR. Participates in basal level of autophagy maintenance by regulating the ubiquitination of EPHB2 and EPHB3.

1. Wang, P. et al. (2013) Cellular signalling 25, 2320-33. PMID: 23896122

2. Ranjan, K. et al. (2021) The Journal of clinical investigation 131. PMID: 34623328

3. Zhang, H. et al. (2021) Autophagy 17, 3030-3047. PMID: 33280498

4. Lear, TB. et al. (2019) The Journal of biological chemistry 294, 16527-16534. PMID: 31586034

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human RNF186 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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