Anti-Human RNF2 Polyclonal Antibody (HA051014)

Name: Anti-Human RNF2 Polyclonal Antibody
Brand: abinScience
SKU: HA051014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Número de catálogo

HA051014

Descripción

Anti-Human RNF2 Polyclonal Antibody (HA051014) is a rabbit polyclonal antibody detecting RNF2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human RNF2 (Glu225-Lys336).

Objetivo

Huntingtin-interacting protein 2-interacting protein 3, RING-type E3 ubiquitin transferase RING2, E3 ubiquitin-protein ligase RING2, HIP2-interacting protein 3, DING, RING finger protein 1B, BAP1, Protein DinG, RING1B, RING finger protein 2, HIPI3, RNF2, RING finger protein BAP-1, RING1b

Purificación

Purified by antigen affinity column.

Número de acceso

Q99496

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

E3 ubiquitin-protein ligase RING2 (RNF2) is a ~37 kDa protein. E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility.

1. Wang, H. et al. (2004) Nature 431, 873-8. PMID: 15386022

2. Cao, R. et al. (2005) Molecular cell 20, 845-54. PMID: 16359901

3. Bentley, ML. et al. (2011) The EMBO journal 30, 3285-97. PMID: 21772249

4. McGinty, RK. et al. (2014) Nature 514, 591-6. PMID: 25355358

5. Gao, Z. et al. (2014) Nature 516, 349-54. PMID: 25519132

6. Taherbhoy, AM. et al. (2015) Nature communications 6, 7621. PMID: 26151332

7. Luo, X. et al. (2021) Human molecular genetics 30, 1283-1292. PMID: 33864376

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human RNF2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human RNF2 Polyclonal Antibody (HA051014)

Vista general

Imágenes

Referencias

Datasheet

SDS