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| カタログ番号 | HA051014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RNF2 Polyclonal Antibody (HA051014) is a rabbit polyclonal antibody detecting RNF2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RNF2 (Glu225-Lys336). | ||||||||
| ターゲット | Huntingtin-interacting protein 2-interacting protein 3, RING-type E3 ubiquitin transferase RING2, E3 ubiquitin-protein ligase RING2, HIP2-interacting protein 3, DING, RING finger protein 1B, BAP1, Protein DinG, RING1B, RING finger protein 2, HIPI3, RNF2, RING finger protein BAP-1, RING1b | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q99496 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | E3 ubiquitin-protein ligase RING2 (RNF2) is a ~37 kDa protein. E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. 1. Wang, H. et al. (2004) Nature 431, 873-8. PMID: 15386022 2. Cao, R. et al. (2005) Molecular cell 20, 845-54. PMID: 16359901 3. Bentley, ML. et al. (2011) The EMBO journal 30, 3285-97. PMID: 21772249 4. McGinty, RK. et al. (2014) Nature 514, 591-6. PMID: 25355358 5. Gao, Z. et al. (2014) Nature 516, 349-54. PMID: 25519132 6. Taherbhoy, AM. et al. (2015) Nature communications 6, 7621. PMID: 26151332 7. Luo, X. et al. (2021) Human molecular genetics 30, 1283-1292. PMID: 33864376 | ||||||||
| 注意事項 | For research use only. |
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