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| カタログ番号 | HY509014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RNH1 Polyclonal Antibody (HY509014) is a rabbit polyclonal antibody detecting RNH1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RNH1 (Asp218-Glu444). | ||||||||
| ターゲット | Ribonuclease inhibitor, Placental ribonuclease inhibitor, Placental RNase inhibitor, Ribonuclease/angiogenin inhibitor 1, RAI, RNH1, PRI, RNH | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P13489 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ribonuclease inhibitor (RNH1) is a ~49 kDa protein. Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG). May play a role in redox homeostasis. Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress. Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus. 1. Teufel, DP. et al. (2003) Biochemistry 42, 1451-9. PMID: 12578357 2. Huang, GH. et al. (2003) Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 35, 960-3. PMID: 14515218 3. Lee, FS. et al. (1988) Biochemistry 27, 8545-53. PMID: 3219362 4. Schneider, R. et al. (1988) The EMBO journal 7, 4151-6. PMID: 3243277 5. Shapiro, R. et al. (1987) Proceedings of the National Academy of Sciences of the United States of America 84, 2238-41. PMID: 3470787 6. Chen, CZ. et al. (1997) Proceedings of the National Academy of Sciences of the United States of America 94, 1761-6. PMID: 9050852 7. Monti, DM. et al. (2007) FEBS letters 581, 930-4. PMID: 17292889 8. Pizzo, E. et al. (2013) Journal of cell science 126, 4308-19. PMID: 23843625 9. Bai, R. et al. (2020) The EMBO journal 39, e103325. PMID: 32510170 | ||||||||
| 注意事項 | For research use only |
Western blot analysis was performed using anti-RNH1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
Lane 2: LO2 cell lysate
Lane 3: Jurkat cell lysate
Lane 4: U87 cell lysate
Lane 5: Raji cell lysate
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