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| カタログ番号 | HD563014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RPE65 Polyclonal Antibody (HD563014) is a rabbit polyclonal antibody detecting RPE65. Suitable for Mouse, Human, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RPE65 (Met1-Ser533). | ||||||||
| ターゲット | All-trans-retinyl-palmitate hydrolase, EC:3.1.1.64, EC:5.3.3.22, Lutein isomerase, Meso-zeaxanthin isomerase, RPE65, Retinal pigment epithelium-specific 65 kDa protein, Retinoid isomerohydrolase, Retinol isomerase | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q16518 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Retinoid isomerohydrolase (RPE65) is a ~60 kDa protein. Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. 1. Moiseyev, G. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 12413-8. PMID: 16116091 2. Jacobson, SG. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 15123-8. PMID: 17848510 3. Shyam, R. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 10882-10887. PMID: 28874556 | ||||||||
| 注意事項 | For research use only |
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