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| カタログ番号 | HF754014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RPS6KA5 Polyclonal Antibody (HF754014) is a rabbit polyclonal antibody detecting RPS6KA5 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RPS6KA5 (Met1-Phe348). | ||||||||
| ターゲット | RPS6KA5, RSK-like protein kinase, MSK1, Ribosomal protein S6 kinase alpha-5, Nuclear mitogen- and stress-activated protein kinase 1, 90 kDa ribosomal protein S6 kinase 5, RSKL, S6K-alpha-5 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75582 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ribosomal protein S6 kinase alpha-5 (RPS6KA5) is a ~89 kDa protein. Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. 1. Wiggin, GR. et al. (2002) Molecular and cellular biology 22, 2871-81. PMID: 11909979 2. Janknecht, R. (2003) Oncogene 22, 746-55. PMID: 12569367 3. Wierenga, AT. et al. (2003) Experimental hematology 31, 398-405. PMID: 12763138 4. Beck, IM. et al. (2008) The EMBO journal 27, 1682-93. PMID: 18511904 5. Deak, M. et al. (1998) The EMBO journal 17, 4426-41. PMID: 9687510 6. New, L. et al. (1999) The Journal of biological chemistry 274, 1026-32. PMID: 9873047 7. Vermeulen, L. et al. (2003) The EMBO journal 22, 1313-24. PMID: 12628924 | ||||||||
| 注意事項 | For research use only. |
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