

| Каталожный номер | HT132014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human RTCA Polyclonal Antibody (HT132014) is a rabbit polyclonal antibody detecting RTCA in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human, Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human RTCA (Met1-Leu366). | ||||||||
| Цель | RNA 3'-terminal phosphate cyclase, RNA cyclase, RNA-3'-phosphate cyclase, 6.5.1.4, RNA terminal phosphate cyclase domain-containing protein 1, RTC domain-containing protein 1, RTCA, RPC, RPC1, RTC1, RTCD1 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | O00442 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | RNA 3'-terminal phosphate cyclase (RTCA) is a ~39 kDa protein. Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. Likely functions in some aspects of cellular RNA processing. Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury. 1. Genschik, P. et al. (1997) The EMBO journal 16, 2955-67. PMID: 9184239 2. Song, Y. et al. (2015) Nature neuroscience 18, 817-25. PMID: 25961792 | ||||||||
| Примечание | For research use only. |
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