

| Numéro de catalogue | HA317014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human RUBCN Polyclonal Antibody (HA317014) is a rabbit polyclonal antibody detecting RUBCN in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human RUBCN (Arg710-Thr972). | ||||||||
| Cible | RUBCN, KIAA0226, Beclin-1 associated RUN domain containing protein, Rubicon, Baron, Run domain Beclin-1-interacting and cysteine-rich domain-containing protein | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q92622 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (RUBCN) is a ~108 kDa protein. Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation. 1. Sun, Q. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 19338-43. PMID: 20974968 2. Sun, Q. et al. (2011) The Journal of biological chemistry 286, 185-91. PMID: 21062745 | ||||||||
| Note | For research use only. |
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