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| カタログ番号 | HP869014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RUVBL2 Polyclonal Antibody (HP869014) is a rabbit polyclonal antibody detecting RUVBL2 in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, Danio rerio, and Xenopus laevis.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RUVBL2 (Gln49-Ser463). | ||||||||
| ターゲット | 48 kDa TATA box-binding protein-interacting protein, RuvB-like 2, INO80 complex subunit J, RUVBL2, TAP54-beta, Reptin 52, TIP60-associated protein 54-beta, TIP48, TIP49B, 51 kDa erythrocyte cytosolic protein, 48 kDa TBP-interacting protein, Repressing pontin 52, INO80J, TIP49b, ECP-51 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Y230 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | RuvB-like 2 (RUVBL2) is a ~51 kDa protein. Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. 1. Kanemaki, M. et al. (1999) The Journal of biological chemistry 274, 22437-44. PMID: 10428817 2. Puri, T. et al. (2007) Journal of molecular biology 366, 179-92. PMID: 17157868 3. López-Perrote, A. et al. (2020) eLife 9. PMID: 33205750 4. Doyon, Y. et al. (2004) Molecular and cellular biology 24, 1884-96. PMID: 14966270 5. Obri, A. et al. (2014) Nature 505, 648-53. PMID: 24463511 6. Jin, J. et al. (2005) The Journal of biological chemistry 280, 41207-12. PMID: 16230350 7. Chen, L. et al. (2011) The Journal of biological chemistry 286, 11283-9. PMID: 21303910 8. Wood, MA. et al. (2000) Molecular cell 5, 321-30. PMID: 10882073 | ||||||||
| 注意事項 | For research use only. |
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