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| カタログ番号 | HB113014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human RXRA Polyclonal Antibody (HB113014) is a rabbit polyclonal antibody detecting RXRA in ELISA, IHC, WB. Suitable for Mouse, Rat, Bovine, Dog, and Danio rerio.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RXRA (Thr223-Thr462). | ||||||||
| ターゲット | Retinoid X receptor alpha, RXRA, Nuclear receptor subfamily 2 group B member 1, NR2B1, Retinoic acid receptor RXR-alpha | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P19793 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Retinoic acid receptor RXR-alpha (RXRA) is a ~50 kDa protein. Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription. The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. 1. Liu, B. et al. (2000) The Journal of biological chemistry 275, 33607-13. PMID: 10874028 2. Harish, S. et al. (2000) Biochemical and biophysical research communications 279, 853-7. PMID: 11162439 3. Tsutsumi, T. et al. (2002) Hepatology (Baltimore, Md.) 35, 937-46. PMID: 11915042 4. Tsai, JM. et al. (2023) Molecular cell 83, 2753-2767.e10. PMID: 37478846 5. Gorla-Bajszczak, A. et al. (1999) Molecular and cellular endocrinology 147, 37-47. PMID: 10195690 6. Jaye, MC. et al. (2005) Journal of medicinal chemistry 48, 5419-22. PMID: 16107141 7. Zhao, WX. et al. (2007) Molecular endocrinology (Baltimore, Md.) 21, 2877-89. PMID: 17761950 8. Chao, EY. et al. (2008) Journal of medicinal chemistry 51, 5758-65. PMID: 18800767 10. Lee, DY. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 2072-2077. PMID: 28167758 | ||||||||
| 注意事項 | For research use only. |
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