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| カタログ番号 | HF811013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1540 | ||||
| ターゲット | S1P receptor 4, S1P receptor Edg-6, Endothelial differentiation G-protein coupled receptor 6, Sphingosine 1-phosphate receptor 4, EDG6, Sphingosine 1-phosphate receptor Edg-6, S1P4, S1PR4 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | O95977 | ||||
| RRID | Anti-Human S1PR4 Antibody (SAA1540) (abinScience Cat# HF811013, RRID:AB_3727301) |
||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Sphingosine 1-phosphate receptor 4 (S1PR4) is a ~41 kDa protein. G protein-coupled receptor highly expressed in immune cells, where it regulates immune response and cytokine production. Functions as a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P). Upon S1P binding, promotes regulatory T-cell differentiation and enhances fatty acid oxidation, through activation of the NRF2/PPARA signaling pathway. Modulates also M1 macrophage activation through interaction with FPR2 and the JNK signaling, contributing to the inflammatory response. In addition, facilitates early neutrophil mobilization and vascular activation during inflammation, promoting lymphocyte recruitment to draining lymph nodes and supporting the development of germinal centers for an effective adaptive immune response. | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human S1PR4 Antibody (SAA1540)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
