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| カタログ番号 | HP056014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SAMHD1 Polyclonal Antibody (HP056014) is a rabbit polyclonal antibody detecting SAMHD1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SAMHD1 (Asp41-Asp583). | ||||||||
| ターゲット | SAM domain and HD domain-containing protein 1, DCIP, Monocyte protein 5, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, MOP5, hSAMHD1, dNTPase, Dendritic cell-derived IFNG-induced protein, MOP-5, SAMHD1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Y3Z3 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 is a ~72 kDa protein. Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. Not able to restrict infection by HIV-2 virus; because restriction activity is counteracted by HIV-2 viral protein Vpx. In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools. 1. Rice, GI. et al. (2009) Nature genetics 41, 829-32. PMID: 19525956 2. Laguette, N. et al. (2011) Nature 474, 654-7. PMID: 21613998 3. Hrecka, K. et al. (2011) Nature 474, 658-61. PMID: 21720370 4. Goldstone, DC. et al. (2011) Nature 480, 379-82. PMID: 22056990 5. White, TE. et al. (2013) Cell host & microbe 13, 441-51. PMID: 23601106 6. Cribier, A. et al. (2013) Cell reports 3, 1036-43. PMID: 23602554 7. Schwefel, D. et al. (2014) Nature 505, 234-8. PMID: 24336198 8. Tang, C. et al. (2015) The Journal of biological chemistry 290, 26352-9. PMID: 26294762 9. Arnold, LH. et al. (2015) PLoS pathogens 11, e1005194. PMID: 26431200 10. White, TE. et al. (2017) Human mutation 38, 658-668. PMID: 28229507 | ||||||||
| 注意事項 | For research use only. |
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