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| カタログ番号 | HA923014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SAR1B Polyclonal Antibody (HA923014) is a rabbit polyclonal antibody detecting SAR1B in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SAR1B (Met1-Asp198). | ||||||||
| ターゲット | GTP-binding protein SAR1b, SAR1B, SARB, GTP-binding protein B, SARA2, GTBPB | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Y6B6 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Small COPII coat GTPase SAR1B is a ~22 kDa protein. Small GTPase that cycles between an active GTP-bound and an inactive GDP-bound state and mainly functions in vesicle-mediated endoplasmic reticulum (ER) to Golgi transport. The active GTP-bound form inserts into the endoplasmic reticulum membrane where it recruits the remainder of the coat protein complex II/COPII. The coat protein complex II assembling and polymerizing on endoplasmic reticulum membrane is responsible for both the sorting of cargos and the deformation and budding of membranes into vesicles destined to the Golgi. In contrast to SAR1A, SAR1B specifically interacts with the cargo receptor SURF4 to mediate the transport of lipid-carrying lipoproteins including APOB and APOA1 from the endoplasmic reticulum to the Golgi and thereby, indirectly regulates lipid homeostasis. In addition to its role in vesicle trafficking, can also function as a leucine sensor regulating TORC1 signaling and more indirectly cellular metabolism, growth and survival. 1. Cutrona, MB. et al. (2013) Traffic (Copenhagen, Denmark) 14, 691-708. PMID: 23433038 2. Melville, DB. et al. (2020) The Journal of biological chemistry 295, 8401-8412. PMID: 32358066 3. Wang, X. et al. (2021) Cell metabolism 33, 350-366.e7. PMID: 33186557 4. Huang, Q. et al. (2023) Proteins 91, 518-531. PMID: 36369712 5. Chen, J. et al. (2021) Nature 596, 281-284. PMID: 34290409 | ||||||||
| 注意事項 | For research use only. |
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