Anti-Human SC5D Polyclonal Antibody (HD502014)

Name: Anti-Human SC5D Polyclonal Antibody
Brand: abinScience
SKU: HD502014
Price: 168 USD
Availability: InStock

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Prix(USD) : --

Spécification :

50ug
100ug

Nombre :

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HD502014

Description

Anti-Human SC5D Polyclonal Antibody (HD502014) is a rabbit polyclonal antibody detecting SC5D. Suitable for Human.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human SC5D (Ser207-Glu299).

Cible

C-5 sterol desaturase, Delta(7)-sterol 5-desaturase, Delta(7)-sterol C5(6)-desaturase, EC:1.14.19.20, Lathosterol 5-desaturase, Lathosterol oxidase, SC5D, SC5DL, Sterol-C5-desaturase

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

O75845

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Contexte

Lathosterol oxidase (SC5D) is a ~35 kDa protein. Catalyzes the penultimate step of the biosynthesis of cholesterol, the dehydrogenation of lathosterol into 7-dehydrocholesterol (7-DHC). Cholesterol is the major sterol component in mammalian membranes and a precursor for bile acid and steroid hormone synthesis. In addition to its essential role in cholesterol biosynthesis, it also indirectly regulates ferroptosis through the production of 7-DHC. By diverting the spread of damage caused by peroxyl radicals from the phospholipid components to its sterol nucleus, 7-DHC prevents this form of cell death.

1. Nishi, S. et al. (2000) Biochimica et biophysica acta 1490, 106-8. PMID: 10786622

2. Freitas, FP. et al. (2024) Nature 626, 401-410. PMID: 38297129

3. Li, Y. et al. (2024) Nature 626, 411-418. PMID: 38297130

Note

For research use only

Images

Reférences

Fiche technique

Anti-Human SC5D Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human SC5D Polyclonal Antibody (HD502014)

Aperçu

Images

Reférences

Fiche technique

SDS