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Anti-Human SCN5A/Nav1.5 Polyclonal Antibody (HC664014)

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Aperçu
Numéro de catalogueHC664014
Description
Anti-Human SCN5A Polyclonal Antibody (HC664014) is a rabbit polyclonal antibody detecting SCN5A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human SCN5A (Ser1787-Gln1931).
Cible Sodium channel protein type V subunit alpha, SCN5A, Sodium channel protein type 5 subunit alpha, hH1, Voltage-gated sodium channel subunit alpha Nav1.5, Sodium channel protein cardiac muscle subunit alpha
Purification Purified by antigen affinity column.
Numéro d'accès Q14524
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Sodium channel protein type 5 subunit alpha (SCN5A) is a ~226 kDa protein. Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat.

1. Gellens, ME. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 554-8. PMID: 1309946
2. Kattygnarath, D. et al. (2011) Circulation. Cardiovascular genetics 4, 261-8. PMID: 21447824
3. Núñez, L. et al. (2013) Heart rhythm 10, 264-72. PMID: 23085483
4. Chakrabarti, S. et al. (2013) Circulation. Arrhythmia and electrophysiology 6, 392-401. PMID: 23420830
5. Gabelli, SB. et al. (2014) Nature communications 5, 5126. PMID: 25370050
6. Wang, L. et al. (2015) Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 36, 2250-62. PMID: 26279430
7. Musa, H. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 12528-33. PMID: 26392562
8. Kinoshita, K. et al. (2016) Heart rhythm 13, 1113-1120. PMID: 26776555
9. Tan, HL. et al. (2001) Nature 409, 1043-7. PMID: 11234013
10. Wang, DW. et al. (2002) Circulation 105, 341-6. PMID: 11804990
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human SCN5A/Nav1.5 Polyclonal Antibody

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