Anti-Human SCN9A Recombinant Antibody (SAA1834) (HS929013)

Anti-Human SCN9A Antibody (SAA1834) (abinScience Cat# HS929013, RRID:AB_3727597)
_x005F_x005F_x000D_ Copy Citation

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Sodium channel protein type 9 subunit alpha (SCN9A/Nav1.7) is a ~226 kDa protein. Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain.