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| カタログ番号 | HS929013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1834 | ||||
| ターゲット | Sodium channel protein type 9 subunit alpha, NENA, Neuroendocrine sodium channel, Sodium channel protein type IX subunit alpha, SCN9A, Voltage-gated sodium channel subunit alpha Nav1.7, PN1, Peripheral sodium channel 1, hNE-Na | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q15858 | ||||
| RRID | Anti-Human SCN9A Antibody (SAA1834) (abinScience Cat# HS929013, RRID:AB_3727597) |
||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Sodium channel protein type 9 subunit alpha (SCN9A/Nav1.7) is a ~226 kDa protein. Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain. 1. Cummins, TR. et al. (2004) The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 8232-6. PMID: 15385606 2. Choi, JS. et al. (2006) Neurology 67, 1563-7. PMID: 16988069 3. Fertleman, CR. et al. (2006) Neuron 52, 767-74. PMID: 17145499 4. Cox, JJ. et al. (2006) Nature 444, 894-8. PMID: 17167479 5. Han, C. et al. (2009) Brain : a journal of neurology 132, 1711-22. PMID: 19369487 6. Eberhardt, M. et al. (2014) The Journal of biological chemistry 289, 1971-80. PMID: 24311784 7. Tan, ZY. et al. (2014) FEBS letters 588, 3964-9. PMID: 25240195 8. Ahuja, S. et al. (2015) Science (New York, N.Y.) 350, aac5464. PMID: 26680203 9. Klugbauer, N. et al. (1995) The EMBO journal 14, 1084-90. PMID: 7720699 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human SCN9A Antibody (SAA1834)
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