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| カタログ番号 | HY176014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SCT Polyclonal Antibody (HY176014) is a rabbit polyclonal antibody detecting SCT in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SCT (Arg19-Arg121). | ||||||||
| ターゲット | Secretin, SCT | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P09683 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Secretin (SCT) is a ~13 kDa protein. Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas. Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid. 1. Afroze, S. et al. (2013) Annals of translational medicine 1, 29. PMID: 25332973 2. Fukuhara, S. et al. (2020) Biochemical and biophysical research communications 533, 861-866. PMID: 33008599 3. Dong, M. et al. (2020) Nature communications 11, 4137. PMID: 32811827 | ||||||||
| 注意事項 | For research use only. |
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