

| Каталожный номер | HY176014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human SCT Polyclonal Antibody (HY176014) is a rabbit polyclonal antibody detecting SCT in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human SCT (Arg19-Arg121). | ||||||||
| Цель | Secretin, SCT | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P09683 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Secretin (SCT) is a ~13 kDa protein. Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas. Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid. 1. Afroze, S. et al. (2013) Annals of translational medicine 1, 29. PMID: 25332973 2. Fukuhara, S. et al. (2020) Biochemical and biophysical research communications 533, 861-866. PMID: 33008599 3. Dong, M. et al. (2020) Nature communications 11, 4137. PMID: 32811827 | ||||||||
| Примечание | For research use only. |
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