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| カタログ番号 | HA065013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1911 | ||||
| ターゲット | Signal peptide, CUB and EGF-like domain-containing protein 2, SCUBE2, Protein CEGP1, Scube/You, CEGP1 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q9NQ36 | ||||
| RRID | Anti-Human SCUBE2 Antibody (SAA1911) (abinScience Cat# HA065013, RRID:AB_3727675) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Signal peptide, CUB and EGF-like domain-containing protein 2 (SCUBE2) is a ~109 kDa protein. Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to increase SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis. 1. Creanga, A. et al. (2012) Genes & development 26, 1312-25. PMID: 22677548 2. Tukachinsky, H. et al. (2012) Cell reports 2, 308-20. PMID: 22902404 3. Jakobs, P. et al. (2014) Journal of cell science 127, 1726-37. PMID: 24522195 4. Lin, YC. et al. (2017) Arteriosclerosis, thrombosis, and vascular biology 37, 144-155. PMID: 27834687 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human SCUBE2 Antibody (SAA1911)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
