

| Каталожный номер | HA016014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human SECISBP2 Polyclonal Antibody (HA016014) is a rabbit polyclonal antibody detecting SECISBP2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human SECISBP2 (Ser638-Leu854). | ||||||||
| Цель | SECISBP2, SECIS-binding protein 2, SBP2, Selenocysteine insertion sequence-binding protein 2 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q96T21 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Selenocysteine insertion sequence-binding protein 2 (SECISBP2) is a ~95 kDa protein. mRNA-binding protein that binds to the SECIS (selenocysteine insertion sequence) element present in the 3'-UTR of mRNAs encoding selenoproteins and facilitates the incorporation of the rare amino acid selenocysteine. Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling. (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation. (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur. 1. Hilal, T. et al. (2022) Science (New York, N.Y.) 376, 1338-1343. PMID: 35709277 | ||||||||
| Примечание | For research use only. |
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