Anti-Human SENP3 Polyclonal Antibody (HP948014)

Name: Anti-Human SENP3 Polyclonal Antibody
Brand: abinScience
SKU: HP948014
Price: 168 USD
Availability: InStock

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Prix(USD) :

Spécification :

50ug
100ug

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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HP948014

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human SENP3 (Glu311-Val574).

Cible

Sentrin-specific protease 3, Sentrin/SUMO-specific protease SENP3, SENP3, SUSP3, SUMO-1-specific protease 3, SSP3

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9H4L4

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Sentrin-specific protease 3 (SENP3) is a ~65 kDa protein. Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1.

1. Gong, L. et al. (2006) The Journal of biological chemistry 281, 15869-77. PMID: 16608850

2. Gao, SS. et al. (2020) Science advances 6, eaba7822. PMID: 32832608

3. Zhang, T. et al. (2022) Nature communications 13, 5133. PMID: 36050397

4. Grégoire, S. et al. (2005) Molecular and cellular biology 25, 2273-87. PMID: 15743823

5. Klein, UR. et al. (2009) Molecular biology of the cell 20, 410-8. PMID: 18946085

6. Huang, C. et al. (2009) The EMBO journal 28, 2748-62. PMID: 19680224

7. Yun, C. et al. (2008) The Journal of cell biology 183, 589-95. PMID: 19015314

8. Haindl, M. et al. (2008) EMBO reports 9, 273-9. PMID: 18259216

9. Fanis, P. et al. (2012) Molecular & cellular proteomics : MCP 11, 1263-73. PMID: 22872859

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human SENP3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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