

| カタログ番号 | HP948014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SENP3 (Glu311-Val574). | ||||||||
| ターゲット | Sentrin-specific protease 3, Sentrin/SUMO-specific protease SENP3, SENP3, SUSP3, SUMO-1-specific protease 3, SSP3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9H4L4 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Sentrin-specific protease 3 (SENP3) is a ~65 kDa protein. Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. 1. Gong, L. et al. (2006) The Journal of biological chemistry 281, 15869-77. PMID: 16608850 2. Gao, SS. et al. (2020) Science advances 6, eaba7822. PMID: 32832608 3. Zhang, T. et al. (2022) Nature communications 13, 5133. PMID: 36050397 4. Grégoire, S. et al. (2005) Molecular and cellular biology 25, 2273-87. PMID: 15743823 5. Klein, UR. et al. (2009) Molecular biology of the cell 20, 410-8. PMID: 18946085 6. Huang, C. et al. (2009) The EMBO journal 28, 2748-62. PMID: 19680224 7. Yun, C. et al. (2008) The Journal of cell biology 183, 589-95. PMID: 19015314 8. Haindl, M. et al. (2008) EMBO reports 9, 273-9. PMID: 18259216 9. Fanis, P. et al. (2012) Molecular & cellular proteomics : MCP 11, 1263-73. PMID: 22872859 | ||||||||
| 注意事項 | For research use only. |
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