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Anti-Human SETD1A Polyclonal Antibody (HC879014)

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Vista general
Número de catálogoHC879014
Descripción
Anti-Human SETD1A Polyclonal Antibody (HC879014) is a rabbit polyclonal antibody detecting SETD1A. Suitable for Human and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human SETD1A (Val1524-Ser1670).
Objetivo EC:2.1.1.364, Histone-lysine N-methyltransferase SETD1A, KIAA0339, KMT2F, Lysine N-methyltransferase 2F, SET domain-containing protein 1A, SET1, SET1A, SETD1A, Set1/Ash2 histone methyltransferase complex subunit SET1, hSET1A
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso O15047
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Histone-lysine N-methyltransferase SETD1A is a ~186 kDa protein. Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis. Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation.

1. Wysocka, J. et al. (2003) Genes & development 17, 896-911. PMID: 12670868
2. Shinsky, SA. et al. (2015) The Journal of biological chemistry 290, 6361-75. PMID: 25561738
3. Higgs, MR. et al. (2018) Molecular cell 71, 25-41.e6. PMID: 29937342
4. Yu, X. et al. (2019) Neuroscience bulletin 35, 1045-1057. PMID: 31197650
5. Kummeling, J. et al. (2021) Molecular psychiatry 26, 2013-2024. PMID: 32346159
6. Amin, HM. et al. (2023) International journal of molecular sciences 24. PMID: 38003223
Nota For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human SETD1A Polyclonal Antibody

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