中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HP214013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, IF, IP, IP-MS | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG1, kappa | ||||
| クローンID | SAA0221 | ||||
| ターゲット | Protein-lysine N-methyltransferase SETD2, HYPB, Histone-lysine N-methyltransferase SETD2, KMT3A, SET2, KIAA1732, Huntingtin yeast partner B, HIF-1, Huntingtin-interacting protein B, Huntingtin-interacting protein 1, HIP-1, Lysine N-methyltransferase 3A, SET domain-containing protein 2, p231HBP, SETD2, HIF1, hSET2 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q9BYW2 | ||||
| RRID | Anti-Human SETD2 IP Antibody (SAA0221) (abinScience Cat# HP214013, RRID:AB_3729755) |
||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||
| 製品使用情報 |
| ||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Histone-lysine N-methyltransferase SETD2 is a ~287 kDa protein. Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. 1. Sun, XJ. et al. (2005) The Journal of biological chemistry 280, 35261-71. PMID: 16118227 2. Yoh, SM. et al. (2008) Genes & development 22, 3422-34. PMID: 19141475 3. Hahn, MA. et al. (2011) PloS one 6, e18844. PMID: 21526191 4. de Almeida, SF. et al. (2011) Nature structural & molecular biology 18, 977-83. PMID: 21792193 5. Zheng, W. et al. (2012) Journal of the American Chemical Society 134, 18004-14. PMID: 23043551 6. Yang, S. et al. (2016) Genes & development 30, 1611-6. PMID: 27474439 7. Yuan, W. et al. (2009) The Journal of biological chemistry 284, 15701-7. PMID: 19332550 8. Carvalho, S. et al. (2013) Nucleic acids research 41, 2881-93. PMID: 23325844 9. Li, F. et al. (2013) Cell 153, 590-600. PMID: 23622243 10. Carvalho, S. et al. (2014) eLife 3, e02482. PMID: 24843002 | ||||
| 注意事項 | For research use only. | ||||
| Isotype Control | Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023) |
SDS-PAGE for Anti-Human SETD2 IP Antibody (SAA0221)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
