

| Número de catálogo | HP870014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Descripción |
Anti-Human SETD7 Polyclonal Antibody (HP870014) is a rabbit polyclonal antibody detecting SETD7 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| Reactividad de especies | Human, Mouse | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human SETD7 (Met1-Lys366). | ||||||||
| Objetivo | Lysine N-methyltransferase 7, SET9, SET7/9, Histone H3-K4 methyltransferase SETD7, SET7, SET domain-containing protein 7, SETD7, H3-K4-HMTase SETD7, KIAA1717, Histone-lysine N-methyltransferase SETD7, KMT7 | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | Q8WTS6 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | Histone-lysine N-methyltransferase SETD7 is a ~40 kDa protein. Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. 1. Wang, H. et al. (2001) Molecular cell 8, 1207-17. PMID: 11779497 2. Nishioka, K. et al. (2002) Genes & development 16, 479-89. PMID: 11850410 3. Xiao, B. et al. (2003) Nature 421, 652-6. PMID: 12540855 4. Martens, JH. et al. (2003) Molecular and cellular biology 23, 1808-16. PMID: 12588998 5. Francis, J. et al. (2005) The Journal of biological chemistry 280, 36244-53. PMID: 16141209 9. Xiao, Y. et al. (2022) Bone research 10, 19. PMID: 35210392 | ||||||||
| Nota | For research use only. |



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